现代检验医学杂志2011，Vol.26Issue(5)：25-28,4.DOI:10.3969/j.issn.1671-7414.2011.05.009
西安地区健康人群ALT与AST参考区间的初步探讨
Study the Reference Intervals for the Hepatic Marker Enzymes ALT and AST
摘要
Abstract
Objective Study the reference intervals for the hepatic marker enzymes ALT and AST in Xi'an. Methods Following multi-center study of IFCC enzyme reference population screening criteria. Blood specimens were collected from 1 098 healthy individuals aged 18-79.including 506 males and 592 females. Activities of ALT and AST were measured distinguish with the Roche detection system with pyridoxal phosphate, the Roche detection system without pyridoxal phosphate and the wako detection system. To study the reference intervals for the hepatic marker enzymes ALT and AST in Xi'an. Results There were some difference between the three systems CP<0. 01). The ALT and AST activities were found to be statistically different between males and females. Therefore, gender-specific reference intervals were established as the Roche detection system with pyridoxal phosphate,ALT-P:10. 24-57. 06 U/L (F),11. 02-84. 00 U/L (M)I AST-Pi 13. 55~50.14 U/L (F),15. 3~53. 42 U/L (M). The Roche detection system without pyridoxal phosphate, ALT-1S7.46~51.34 U/L (F),9. 09-71. 06 U/L (M):AST-1:11. 89~40. 49 U/L (F),13. 6~40. 52 U/L (M).The Wako detection system ALT:6. 41 - 41. 73 U/L (F),7. 2167. 77 U/L (M); AST:9. 41 -40. 64 U/L (F),12.1-41. 11 U/L (M). Conclusion The reference upper limits of the two enzymes in Xi'an population compared with others similar studies are higher. There were some difference between the three systems (P<0. 01). The reference range of Roche reagent with pyridoxal phosphate was higher than the reference range of Roche reagent without pyridoxal phosphate. The former was 15% to 20% higher than the latter. But the reference range of Roche reagent without pyridoxal phosphate was higher than the reference range of Wako reagent without pyridoxal phosphate,the former was higher than the latter 10%. The reference range of Wako reagent without pyridoxal phosphate was higher than the reference range currently used in clinical.关键词
丙氨酸氨基转移酶(ALT)/天冬氨酸氨基转移酶(AST)/磷酸吡哆醛/参考区间Key words
alanine aminotransferase/aspartate aminotransferase /pyridoxal phosphate /reference intervals分类
医药卫生引用本文复制引用
周铁成,张莹,童开,岳乔红,郝晓柯..西安地区健康人群ALT与AST参考区间的初步探讨[J].现代检验医学杂志,2011,26(5):25-28,4.基金项目
国家高技术研究发展计划(863计划)资助项目(2006B020909). （863计划）
