重庆医学2011，Vol.40Issue(29)：2918-2921,4.DOI:10.3969/j.issn.1671-8348.2011.29.003
体外心脏震波治疗冠心病的有效性研究
A study on the effectiveness of extracorporeal cardiac shock wave therapy for treatment of coronary artery disease*
摘要
Abstract
Objective To evaluate the feasibility,security and efficiency of extracorporeal cardiac shock wave therapy (CSWT) for treatment of coronary artery disease. Methods A total of 25 patients with old myocardial infarction(OMI without thrombolysis or PCI or CABG) were included in this study(mean age 65 years old). According to random digits table, using the method of Double-Blind, patients were divide into the experimental group (14 patients were treated with shock wave, 200 shots/spot at 0.09 mJ/mm2 for 9 spots,amount to 9 times within 3 month) and the placebo control group (11 patients were treated with the same procedures but without shock wave). Before and after treament,all patients received the examinations include the 99mTc-MIBI myocardial perfusion SPKCT and the 18F-FDG myocardial metabolism SPKCT,Canadian Cardiovascular Society (CCS) class sores, NYHA, Seattle Angina Questionnaire(SAQ) , 6-min walk test(6MWT) , Left ventricular ejection fraction ( LVEF) , nitroglycerin dosage and so on. The changes of the mortality, rehospitalization, myocardial perfusion and myocardial metabolism between before and after shock wave therapy were detected, in placebo control group and experimental group during follow up (8. 40 + 1. 84) months. Results Twenty-five patients completed the therapy based on the method of Double-Blind,didn't occur procedural complications or adverse effects. There was no dead patient in the placebo control group,but 1 patient died in the experimental group(P> 0. 05). 7 patients suffered from rehospitalization,2 in the experimental group and 5 in the placebo control group(P>0. 05). After treatment of CSWT,the NYHA,CCS class sores and the dose of nitroglycerin were less than that of pretherapy in the experimental group (P<0. 05), but SAQ, 6 MWT, myocardial perfusion, myocardial metabolism, and LVEF were more than that of pretherapy (P<0. 05). Whereas,all the parameters of the placebo control group didn't have significant change(P>0. 05). Conclusion Extra-corporeal cardiac shock wave therapy is safe, non-invasive and effective for CAD in ameliorating anginal symptoms, heart function and exercise tolerance which was associated by a substantial reduction of ischemic myocardium.关键词
心肌梗死/新生血管化,生理性/体外心脏震波/治疗,临床研究性Key words
myocardial infarction/neovascularization,physiologic/extracorporeal cardiac shock wave therapy/therapies,investigational引用本文复制引用
杨萍,杨洪文,郭涛,彭云珠,王钰,周平,蔡红雁,骆志玲,赵玲,顾云..体外心脏震波治疗冠心病的有效性研究[J].重庆医学,2011,40(29):2918-2921,4.基金项目
云南省社会攻关项目(2006SG10) （2006SG10）
云南省社会发展计划项目(2008CD007). （2008CD007）
