医学分子生物学杂志2011，Vol.8Issue(5)：424-428,5.DOI:10.3870/j.issn.1672-8009.2011.05.010
子宫内膜癌组织中生长抑素受体、VEGF的表达及其与血管形成的关系
Expression of Somatostatin Receptor and VEGF in Endometrial Carcinoma and Their Relationship to Angiogenesis
黄素真 1黄双英1
作者信息
- 1. 福建医科大学附属第二医院妇产科,福建省泉州市,362000
- 折叠
摘要
Abstract
Objective To investigate the expression of somatostatin receptor ( SSTR) and VEGF in endometrial carcinoma and their relationship to angiogenesis. Methods The expression of SSTR, VEGF in the paraffin-embedded section of 60 cases of endometrial carcinoma and 26 cases of normal endometrium was evaluated by immunohistochemistry technique. Microvessel density ( MVD) of endometrial carcinoma and normal endometrium was also determined with anti-CD34 as the maker. The relation between expression of SSTR and VEGF to the clinicopathological parameters and the expression of CD34 were analyzed. Results The positive rate of SSTR subtypes in 60 endometrial cancers was 70 % for SSTR1, 15 % for SSTR2, 21.7 % for SSTR3, 233 % for SSTR4 and 18.3 % for STR5 , respectively. The expression of SSTR3 , SSTR4 in middle and well differentiated groups was significantly higher than that in poorly differentiated group (P < 0. 05) . The positive rate of VEGF in endometrial carcinoma ( 83. 33 % ) was higher than in normal endometrium (30. 76 % ) (P < 0. 05) . The level of VEGF expression was significantly associated with clinical stage, histological grade and the depth of invasion myometrium (P < 0. 05) . The positive rate of MVD in endometrial carcinoma was higher than that in normal endometrium. SSTR5 shwoed negative correlation with VEGF, while VEGF positive expression was highly correlated with MVD. Conclusion Expressions of SSTR and VEGF are related with prognostic assessment in endometrial carcinoma. A subgroup of receptor-positive endometrial cancers may be a potential target fortreatment with somatostatin receptor subtype analogs (SSTA) .关键词
子宫内膜肿瘤/生长抑素/受体/VEGF/CD34/免疫组织化学Key words
endometrial carcinoma/ somatostatin/ receptor/ VEGF/ CD34/ immunohisto-chemistry分类
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黄素真,黄双英..子宫内膜癌组织中生长抑素受体、VEGF的表达及其与血管形成的关系[J].医学分子生物学杂志,2011,8(5):424-428,5.
