疑难病杂志2011，Vol.10Issue(11)：829-831,3.DOI:10.3969/j.issn.1671-6450.2011.11.011
小剂量甲状腺素在慢性阻塞性肺疾病患者机械通气中的应用价值
The value of low-dose thyroxin in chronic obstructive pulmonary disease with mechanical ventilation
赵军魁 1王云辉 1王永军 2赵现彬 1武巧云 1张小科 1徐俊华1
作者信息
- 1. 056200,邯郸,冀中能源峰峰集团有限公司总医院ICU科
- 2. 050041,石家庄,河北省胸科医院心内科
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effect of low-dose thyroxin in chronic obstructive pulmonary dis-ease( COPD ) with mechanical ventilation. Methods Sixty-seven patients who suffered from chronic obstructive pulmonary disease combined with respiratory failure and treated with mechanical ventilation were randomized allocated into conventional treatment group ( group A, n = 32 ) and thyroxin group ( group B, n = 35 ) which with additional oral thyroxin at the daily dose of 20 mg. The levels of T3 ,T4 and TSH in serum and the average changes of their heart rates,PaO2 and PaCO2 were recorded. Weaning succeed rate and the time of mechanical ventilation were observed and compared. Results The levels of T3 and T4 in group B increased obviously after treatment within 3 days, and PaO2 and PaCO2 were improved significantly( P < 0. 05 ), these levels improved to normal range at 5th day. The levels of TSH and heart rate didn't change obviously( P > 0.05 ). Compared with group A, the levels of T3, T4 , heart rate, PaO2 and PaCO2 in group B were improved significantly at all-time points ( P <0.05 ), while these levels did not change obviously in group A after treatment (P >0. 05 ). The weaning succeed rate in group B were better than group A, and the time of mechanical ventilation in group B were obviously shorter than group A ( P < 0. 05 ). Conclusion Low dose thyroxin is safe and can improve therapeutic effect significantly in chronic obstructive pulmonary disease with mechanical ventilation.关键词
甲状腺素/肺疾病,阻塞性,慢性/机械通气Key words
Thyroxin/ Pulmonary disease, obstructive, chronic/ Mechanical ventilation引用本文复制引用
赵军魁,王云辉,王永军,赵现彬,武巧云,张小科,徐俊华..小剂量甲状腺素在慢性阻塞性肺疾病患者机械通气中的应用价值[J].疑难病杂志,2011,10(11):829-831,3.
