肝胆胰外科杂志2011，Vol.23Issue(5)：360-363,4.
N-乙酰半胱氨酸预处理对肝脏缺血再灌注损伤的保护作用
Protective effects of NAC preconditioning on hepatic ischemia reperfusion injury
摘要
Abstract
Objective To probe the protective effects of N-acetylcysteine (NAC) preconditioning on hepatic ischemia reperfusion injury. Methods Eighteen patients undergone hepatic haemangioma resection were allocated randomly into three groups (n=6): control group (CO), NAC preconditioning group (PR) injected with NAC 120 mg/kg before hepatic inflow occlusion (T0), NAC postconditioning group (PO) with NAC injected after hepatic vascular release. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined separately before skin incision (T0), at 1 h (T1) and 6 h (T2) after hepatic vascular re-lease. Malondialdehyde (MDA) contents and the activities of nuclear factor-KB (NF-kB) in liver tissue were detected at 1 h after hepatic vascular release. Results The serum levels of ALT and AST at 1 h (T1) and 6 h (T2) after hepatic vascular release increased markedly as compared to those before hepatic inflow occlu-sion (T0) in all three groups. Compared with that of CO group, the contents of MDA were lower in both PR and PO groups (P<0.05), while the reduced binding activity of nuclear factor-kB in liver tissue was only observed in PR group (P<0.01), but not in PO group. Conclusion NAC preconditioning can protect hepatic ischemia and reperfusion injury, mainly by inhibiting the trigger of the activation of nuclear factor-kB.关键词
N-乙酰半胱氨酸/肝脏/缺血再灌注损伤/丙二醛/NF-κBKey words
N-acetylcysteine/ liver/ ischemia-reperfusion injury/ malondialdehyde (MDA)/ nuclear factor-kB分类
医药卫生引用本文复制引用
庄永敬,曹云飞,薛蓬,刘小红,卢良生,吴桂荣..N-乙酰半胱氨酸预处理对肝脏缺血再灌注损伤的保护作用[J].肝胆胰外科杂志,2011,23(5):360-363,4.基金项目
国家自然科学基金资助项目(C30000158). （C30000158）
