安徽医科大学学报2011，Vol.46Issue(10)：1029-1031,3.
盐酸吡格列酮对糖尿病大鼠尿nephrin排泄的影响
Effect of different dosages of pioglitazone on the excretion of urinary nephrin in STZ-induced diabetic rats
摘要
Abstract
To observe the effect of different dosages of hydrochloride pioglitazone( PIO ) on the excretion of urinary sediment nephrin( UNE ) in STZ-induced diabetic rats, and to investigate the protective effects of thi-azolidinediones( TZDs ) on podocyte. Methods 32 STZ-induced diabetic rats were randomly divided into following four groups: model diabetic rats( DM group ), 10,20 and 30 mg/( kg · D )PIO-treated diabetic rats( DR1 ,DR2 and DR3 group,respectively, n =8 ),in addition, 8 healthy rats were served as normal control group( NC group ). The peripheral blood glucose( BG),glycated haemoglobin( HbAlc ),urinary albumin( UACR),UNE and urinary creati-nine were measured in the experimental period. Results (J) The BG and HbAlc levels in all diabetic rats were significantly increased ( P <0. 01,versus group NC ),but no significant differences among diabetic rats. (2) At the 4th week, UACR was significantly decreased in DR2 and DR3 group ( P < 0. 01, versus group DM ), which in DR1 group decreased slightly; At the 8 th week, UACR in PIO-treated group was significantly lower than that of DM group, which in DR2 and DR3 group were significantly lower than that of DR1 group. (3) At the first day, UNE could be detected in five groups, but no significant differences; At the 4th week, UNE was significantly reduced in PlO-treated groups( P < 0. 05, versus DM group ), but no differences among the PIO-treated groups; At the 8th week, UNE was significantly reduced in PlO-treated groups( P <0. 05, versus DM group ). UNE was significantly decreased in DR2 and DR3 group( P < 0. 05, versus DR1 group ), but no difference between DR2 and DR3 group. (4) Pearson correlation analysis showed that UNE was positively correlated with UACR( r =0. 881 ,P <0. 01 ). Conclusion PIO can restrain UNE with a dose-dependent mode.关键词
糖尿病肾病/足细胞/蛋白尿/噻唑烷二酮类Key words
diabetic nephropathy/ podocytes/ proteinuria/ thiazolidinediones分类
医药卫生引用本文复制引用
匡蕾,叶山东,刑燕,陈玉米..盐酸吡格列酮对糖尿病大鼠尿nephrin排泄的影响[J].安徽医科大学学报,2011,46(10):1029-1031,3.基金项目
安徽省自然基金项目(项目编号:070413255X) （项目编号:070413255X）
安徽省人事厅高级人才资助项目(项目编号:2008Z048) （项目编号:2008Z048）
