医学分子生物学杂志2011，Vol.8Issue(5)：382-385,4.DOI:10.3870/j.issn.1672-8009.2011.05.002
肿瘤坏死因子α基因启动子区多态性与皖南地区Graves病发生的关系
Association of Tumor Necrosis Factor-α Gene Promoter Polymorphisms with Graves' Disease in Southern Anhui
摘要
Abstract
Objective To investigate the association of tumor necrosis factor-α (TNF-α) gene promoter polymorphisms with Graves' Disease ( GD) in Chinese Hans residing in southern Anhui. Methods TNF-a gene polymorphisms at position-238 and-308 were determined with the TaqMan probe allelic discrimination method and compared in 432 cases of GD with 629 controls. Results There were no significant differences in genotypic or allelic frequencies between GD group and control group (P > 0. 05) . There was no significant difference in genotypic or allelic frequencies among clinical characteristics groups. Conclusion TNF-α-238G/A and-308 G/A polymorphisms may be not associated with GD in Chinese Hans residing in southern Anhui.关键词
肿瘤坏死因子/Graves病/基因多态性Key words
tumor necrosis factor/ Graves' disease/ gene/ polymorphism分类
医药卫生引用本文复制引用
孙玲玲,褚迅..肿瘤坏死因子α基因启动子区多态性与皖南地区Graves病发生的关系[J].医学分子生物学杂志,2011,8(5):382-385,4.基金项目
安徽省高校省级自然基金研究项目(No.KJ2011B190) （No.KJ2011B190）
