中国医学科学院学报2011，Vol.33Issue(4)：397-401,5.DOI:10.3881/j.issn.1000-503X.2011.04.010
拉萨地区藏族人群17个短串联重复序列基因座的遗传多态性
Polymorphism of 17 Short Tandem Repeat Loci of Tibetan Minority Ethnic Group from Lhasa
马骏 1巴华杰 1张文杰 1李开2
作者信息
- 1. 江苏省常州市公安局刑事警察支队,江苏常州213003
- 2. 南京医科大学法医学系,南京210029
- 折叠
摘要
Abstract
Objective To investigate the polymorphism of 17 short tandem repeat (STR) loci of Tibetan minority ethnic group from Lhasa. Methods Blood samples were obtained from 132 unrelated Tibetan individuals from Lhasa. DNA templates were screened by home-made AGCU17 + 1 kit and 3130XL genetic analyzer. Genotyping was performed using GeneMapper software (version 3. 2). Results The allele frequencies of 17 STR loci ranged 0. 0038-0. 5720, and the power of discrimination ranged 0. 779-0. 979, the power of exclusion ranged 0.327-0.737, the polymorphism information contents ranged 0.538-0.910, and the het-erozygosity ranged 0. 629-0. 871. The cumulative coupling probability was 3. 93 x 10"20, and the cumulative power of exclusion was 0. 9999995234. Of 17 STR loci, Penta E and D6S1043 had the highest polymorphism indicators, while TPOX had the lowest Conclusion The 17 STR loci used in this study are highly polymorphism in Tibetan minority ethnic group from Lhasa and fit for the population genetic study and forensic cases.关键词
短串联重复序列/遗传多态性/群体遗传学/藏族Key words
short tandem repeat/ genetic polymorphism/ population genetic analysis/ Tibetan分类
生物科学引用本文复制引用
马骏,巴华杰,张文杰,李开..拉萨地区藏族人群17个短串联重复序列基因座的遗传多态性[J].中国医学科学院学报,2011,33(4):397-401,5.
