中国医学科学院学报2011，Vol.33Issue(4)：421-426,6.DOI:10.3881/j.issn.1000-503X.2011.04.014
女性人类免疫缺陷病毒相关脂肪营养不良综合征患者体成分变化特点
Change in Body Compositions in Female Patients with Human Immunodeficiency Virus-related Lipodystrophy Syndrome
摘要
Abstract
Objective To study the changes of body composition in females patients with human immunodeficiency virus ( HIV)-related lipodystrophy (LD) syndrome (HIV-LD). Methods Totally 25 female patients who were treated in our hospital from January 2002 to December 2009 were divided into LD group and non-LD group based on the existence of LD. All these patients were receiving highly active antiretroviral therapy ( HAART). In addition, 12 healthy women were set as the controls. Total and regional body composition were measured by dual X-ray absorptiometry in all three groups. Results The fat mass ( FM) was correlated negatively with the duration of HAART (r = -0. 431, P =0. 029). Multiple linear regression analysis showed thatFM had positive correlation with weight and negative correlation with lean mass ( LM ) ( r = - 0. 973 , P = 0. 000). Total, trunk and leg FM were significantly lower in ID patients than that in controls (P < 0. 05 ). Meanwhile, total, trunk and leg bone mineral contents were statistically lower in LD patients than that in controls ( P < 0. 05 ). Lumbar bone mineral density of LD patients was lower than that of non-LD patients and controls, and there was significant difference between LD patients and controls (P =0. 001). LM of LD patients was higher than that of non-LD patients but without statistical difference ( P > 0. 05). Conclusions The peripheral and central FM and bone mineral contents remarkably decrease in female patients with HIV-LD. However, HIV-LD patients tend to have higher LM than non-LD patients.关键词
人类免疫缺陷病毒/脂肪营养不良/脂肪量/骨矿量/肌量/骨密度Key words
human immunodeficiency virus/ lipodystrophy/ fat mass/ bone mineral content/ lean mass/ bone mineral density分类
医药卫生引用本文复制引用
姚金朋,余卫,李太生,罗玲,林强,田均平,畅银娟..女性人类免疫缺陷病毒相关脂肪营养不良综合征患者体成分变化特点[J].中国医学科学院学报,2011,33(4):421-426,6.基金项目
国家十一五科技重大专项课题(2008ZX10001-006)和卫生部临床重点学科艾滋病研究项目(2007-2009) Supported by the National Key Technologies R&D Program for the 11 th Five-year Plan (2008ZX10001-006) and Ministry of Health Clinical HIV/AIDS Research Grant (2007-2009) （2008ZX10001-006）
