北京中医药大学学报2011，Vol.34Issue(8)：565-568,4.
运用相关性分析方法探讨抑郁症中医核心病机的研究
Kernel TCM pathogenesis of depression investigated with correlation analysis
摘要
Abstract
Objective To analyse the relationship between the principal symptoms of depression and multiple TCM syndromes by using correlativity analysis method, and decide the kernel TCM pathogenesis of depression based on the degree of correlativity. Methods The symptoms in depression patients were reviewed by applying Hamilton Depression Scale (HAMD), and 115 symptoms were taken as indexes to established the Observation Table of TCM Syndromes of Depression for assessing TCM symptoms. The review on TCM symptoms and scales of Western medicine was carried out in 1 221 cases and then the data were inputted into database. The scores of 16 TCM syndrome factors and 7 HAMD factors were calculated and the correlativity was studied for observing the highest correlativity between principal symptom and TCM syndrome and determining the kernel TCM pathogenesis of depression. Results HAMD retardation factors (including the principal symptoms of depression such as depressed mood, declined interest and work ability, tardy and hypaphrodisia) had the highest correlativity to kidney deficiency ' factor showing positive correlation ( correlative coefficient was 0. 290), and negatively related to liver depression and fire derived by liver depression. HAMD anxiety/somatization factors (including neurotic anxiety, somatic anxiety, gastrointestinal symptoms, hypochondriasis and insight, and general symptoms) had the highest correlativity to fire derived by liver depression ( correlative coefficient was 0. 476 ). Conclusion Kidney deficiency is a principal pathogenesis of depression.关键词
抑郁症/中医证候/病机/相关性分析Key words
depression/ TCM syndromes/ pathogenesis/ correlation analysis分类
医药卫生引用本文复制引用
曲淼,唐启盛,裴清华,李侠..运用相关性分析方法探讨抑郁症中医核心病机的研究[J].北京中医药大学学报,2011,34(8):565-568,4.基金项目
首都医学发展基金重大联合攻关项目(No:03-I-02),获得2010年度国家科技进步二等奖 （No:03-I-02）
