国际病理科学与临床杂志2011，Vol.31Issue(4)：296-300,5.DOI:10.3969/j.issn.1673-2588.2011.04.005
极性蛋白与中枢神经系统发育
Polarity proteins in central nervous system development
摘要
Abstract
The diversity of neuronal morphologies and the complexity of synaptic connections in the mammalian brain provide classical examples for cell polarity. Both the establishment and maintenance of neuronal polarity require the regulation of polarity protein. It is well known that there is a mechanism of evolution conservation for polarity protein from the C. Elegans zygote development to mammalian neuronal polarization. The conserved polarity proteins regulate neurogenesis, neurite outgrowth, neuronal migration and synaptogenesis in central nervous system (CNS). The process of central nervous system development, including neurogenesis, neuronal migration, neurite outgrowth, and synaptogenesis, depends on well-coordinated polarity proteins and reciprocal interaction dynamics.关键词
极性蛋白/中枢神经系统发育/神经发生/轴突形成/突触发生Key words
polarity protein/central nervous system development/neurogenesis/axon outgrowth/synaptogenesis引用本文复制引用
赵婧..极性蛋白与中枢神经系统发育[J].国际病理科学与临床杂志,2011,31(4):296-300,5.基金项目
国家自然科学基金项目(30825039,30973236,30770748) （30825039,30973236,30770748）
四川省科技厅基金(08ZQ026-069) （08ZQ026-069）
长江学者和创新团队发展计划(IRT0935).The work was supported by National Natural Science Foundation of China (30825039,30973236,30770748),Foundation of Department of Science and Technologyof Sichuan Province(08ZQ026-069),Program of Changjiang Scholars and Innovative Research Team inUniversity( IRT0935),P.R.China. （IRT0935）
