国际病理科学与临床杂志2011，Vol.31Issue(4)：319-322,4.DOI:10.3969/j.issn.1673-2588.2011.04.010
高迁移率族蛋白A1与2型糖尿病
High mobility group protein A1 and Type 2 diabetes
摘要
Abstract
High mobility group protein Al (HMGAl), as a specific cofactor for gene activation, has no intrinsic transcriptional activity alone. However, it can activate promoters through mechanisms to maintain the stability of stereospecific DNA-protein complexes for gene transcription. HMGAl, by affecting the expression of insulin receptor and insulin-like growth factor 1 receptor, can reduce insulin secretion and impair adipocyte differentiation, which leads to insulin resistance and Type 2 diabetes. However, HMGAl-knockout mice were actually hypersensitive to insulin. The difference of insulin sensitivity between human and mouse peripheral tissue may be related to retinol-binding protein.关键词
高迁移率族蛋白A1/2型糖尿病/胰岛素受体/视黄醇结合蛋白Key words
high mobility group protein Al/Type 2 diabetes/insulin receptor/retinol-binding protein引用本文复制引用
朱颖杰..高迁移率族蛋白A1与2型糖尿病[J].国际病理科学与临床杂志,2011,31(4):319-322,4.基金项目
国家自然科学基金(81170807) （81170807）
衡阳市科技计划项目(200612).This work was supported by the National Natural Science Foundation of China (81170807) and Scientific and Technological Program of Hengyang,Hunan Province,P.R.China (200612). （200612）
