国际病理科学与临床杂志2011，Vol.31Issue(4)：315-318,4.DOI:10.3969/j.issn.1673-2588.2011.04.009
动脉粥样硬化中巨噬细胞凋亡与内质网应激机制
Macrophage apoptosis and the mechanisms of endoplasmic reticulum stress in atherosclerosis
崔淑华1
作者信息
- 1. 南华大学药物药理研究所,湖南衡阳421001
- 折叠
摘要
Abstract
Macrophages are important cell component of the immune system with multiple functions and play crucial roles in the development of atherosclerosis and other vascular diseases. Macrophage apoptosis is a key factor leading to instability of atherosclerotic plaques. In the late stage of atherosclerosis, macrophage apoptosis is closely related to endoplasmic reticulum ( ER) stress. Macrophage apoptosis is mediated by two central pathways; the extrinsic (or death receptor) pathway and the intrinsic (or mito-chondrial, endoplasmic reticulum stress) pathway. The later has been found for a few years but the mechanisms still remain poorly understood.关键词
巨噬细胞/凋亡/内质网应激/动脉粥样硬化Key words
macrophage/apoptosis/endoplasmic reticulum stress/atherosclerosis引用本文复制引用
崔淑华..动脉粥样硬化中巨噬细胞凋亡与内质网应激机制[J].国际病理科学与临床杂志,2011,31(4):315-318,4.
