激光生物学报2011，Vol.20Issue(4)：542-547,6.DOI:10.3969/j.issn.1007-7146.2011.04.021
维生素C对光化学法诱导皮肤光损伤 的光保护作用:OCT定量研究
Quantitative Analysis on PUVA-induced Skin Lesions and the Photoprotective Effect Induced by Vitamin C Using Optical Coherence Tomography
摘要
Abstract
Psoralen plus ultraviolet A radiation (PUVA) therapy is a very important clinical treatment of skin diseases such as vitiligo and psoriasis, but associated with an increased risk of skin photodamages. To study the photoprotective effect of vitamin C( Vc) to PUVA induced photodamaged skin, 7.5% 、15% 、30% Vc solutions were applied to PUVA induced photodamaged skin of the Balb/c mice daily for 3 days. OCT was introduced to measure the antioxidant protection factor by analysis of the changes in optical parameters. The results showed that Vc treatment group had a decrease in shin thickness and an increase in attenuation coefficient. In conclusion, the vitamin C treatment, especially 15% Vc solution treatment, may promote the repair process of photodamage.关键词
光学相干层析成像/皮肤/光化学疗法/光损伤/维生素CKey words
optical coherence tomography (OCT)/ skin/ PUVA/ photodamage/ vitamin C分类
医药卫生引用本文复制引用
王传兴,翟娟,刘智明,郭周义..维生素C对光化学法诱导皮肤光损伤 的光保护作用:OCT定量研究[J].激光生物学报,2011,20(4):542-547,6.基金项目
国家自然科学基金项目(60778047) （60778047）
教育部博士学科点专项科研基金项目(200805740003) （200805740003）
