解剖学杂志2011，Vol.34Issue(4)：436-438,453,4.
人胚胎脊髓发育过程中神经营养因子3的表达及变化
Expression of neurotrophin-3 in the human embryo spinal cord
摘要
Abstract
Objective:To explore the expression change and its significance of neurotrophin-3 (NT-3) at different developmental stages of human embryonic spinal cord. Methods : Immunohistochemistry and Western blot were used to systematically study the localization and quantitation of NT-3 in the human embryonic spinal cord from the 4th week to the 7th month. Results:NT-3 positive protein was found in all the detected 11 time points, and concentrated on cell process and fiber. A-long with the embryonal age the quantitation of NT-3 increased gradually from the 6th week, reached the peak in the 9th week, and then decreased and maintained at a certain level. Conclusion: NT-3 is widely distributed in human fetal spinal cord of different developmental stages and may play an vital role in the embryonic stage. NT-3 possibly has an positive role in the Idivision, proliferation and differentiation of the spinal neural stem cells.关键词
神经营养因子3/人胚胎/脊髓/发育Key words
neurotrophin-3/ human fetus/ spinal cord (development引用本文复制引用
郭建辉,杨金伟,贺永胜,高燕,殷露玮,冯忠堂,李力燕..人胚胎脊髓发育过程中神经营养因子3的表达及变化[J].解剖学杂志,2011,34(4):436-438,453,4.基金项目
云南省自然科学基金(2004C0003R,2007C219M, 2008ZC108M) （2004C0003R,2007C219M, 2008ZC108M）
