解剖学杂志2011，Vol.34Issue(4)：472-475,4.
电针对单纯性肥胖大鼠无排卵机制的影响
Mechanism underlying the electric acupuncture improves the anovulation in simple obesity rats
摘要
Abstract
Objective: To explore the effects of electric acupuncture on the ovulating mechanism in obese rats induced by high fat diet Methods:The obese infertile rats were duplicated by fed high-energy diet to ablactated female SD rats, and then, were randomly untreated used as control or treated with electric acupuncture. The expression of neuropeptide Y (NRY) and gonadotropin-releasing hormone (GnRH) in the arcuate nucleus of hypothalamus, and levels of estradiol (E2), testosterone (T) , leptin, follicle stimulating hormone (FSH) and luleinizing hormone (LH) in serum were detected. The parameters a-bove-mentioned were analyzed among the normal rats, which were fed with normal diet, control rats and electric acupuncture treated rats. Results: Compared with control rats, electric acupuncture caused significant decrease in levels of E2, T and leptin, and increase in levels of FSH and LH in serum. In the arcuate nucleus of hypothalamus, the expression of NPY was down-regulated, while the expression of GnRH was up-regulated due to the application of electric acupuncture. Conclusion:Electric acupuncture can depress the proportion of anovulatory infertility induced by obesity through modulating the neuroen-docrine metabolism and reducing dysfunction of the hypothalamus-pituitary-ovarian axis.关键词
电针/神经肽Y/促性腺激素释放激素/肥胖/不孕/大鼠Key words
electric acupuncture/ neuropeptide Y/gonadotropin-releasing hormone/ obesity/ infertility/ rat引用本文复制引用
张洪芹,赵方欣..电针对单纯性肥胖大鼠无排卵机制的影响[J].解剖学杂志,2011,34(4):472-475,4.基金项目
山东省自然科学基金(Y2008C74) （Y2008C74）
