实用妇产科杂志2011，Vol.27Issue(8)：587-591,5.
转录因子FOXP3基因多态性与不明原因复发性自然流产的易感性研究
Genetic Susceptibility of the Transcription Factor FOXP3 Gene in Unexplained Recurrent Spontaneous Abortion
摘要
Abstract
Objective:To investigate and clarify whether the genetic susceptibility to women with unexplained recurrent spontaneous abortion (URSA) is associated with polymorphisms of transcription factor FOXP3 gene. Methods:Polymerase chain reaction with sequence-specific primers (PCR-SSP) was used to genotype FOXP3 gene loci rs2232365A/G、rs5902434del/ATT in 146 URSA cases (URSA group) and 112 normal controls. Results:①The distribution frequencies of rs2232365A/G associated 3 genotypes between the URSA and control group showed statistically significant difference( P=0. 016) ,and the risk of URSA was higher in the carriers of G allele than that of A allele( P=0. 01 ,OR=1. 61). ②There was no difference in the genotypic distribution of rs5902434 del/ATT polymorphism between URSA group and control group, but the del allelic frequency was statistically increased in patients with URSA, as compared to controls (P=0.036, OR = 1.49 ). ③Haplotype analysis: Haplotype G/del obviously increased the onset risk of URSA (P=0. 02, OR = 1. 53) and haplotype A/ATT was the protection factor( P=0. 02,OR=0. 63). Conclusions:The transcription factor FOXP3 gene polymorphisms in promoter rs2232365 and rs5902434 is association with URSA, and the G or del allele is a risk factor for URSA.关键词
不明原因复发性自然流产/遗传多态性/转录因子FOXP3Key words
Unexplained recurrent spontaneous abortion/ Genetic polymorphism/ Transcription Factor FOXP3分类
医药卫生引用本文复制引用
吴再归,游泽山,张彩,李珠玉,苏秀梅,张秀明,李银广..转录因子FOXP3基因多态性与不明原因复发性自然流产的易感性研究[J].实用妇产科杂志,2011,27(8):587-591,5.基金项目
广东省科技计划项目(编号:2008B030301072,2008B030301096) （编号:2008B030301072,2008B030301096）
