实用妇产科杂志2011，Vol.27Issue(8)：607-611,5.
1624例不孕不育患者中染色体核型异常184例分析
Clinical Analysis of 184 Cases with Chromosomal Abnormality in 1624 Infertility Patients
摘要
Abstract
Objective:To study the relationship between chromosome abnormity and their phenotype, and analyze the detection rate of abnormal chromosome, abnormal phenotype and frequency distribution. Methods: Among 1624 patients consulted in infertility clinic in our hospital from recent 6 years, chromosome kary-otype and clinical analysis were conducted in abnormal chromosome patients. Results:Out of 1624 infertility patients, 184 cases were with chromosome abnormity. The numbers of euchromosome abnormalities were 79 (42.93%). The number of sex chromosome abnormalities and abnormal sex chromosome structure were 31 and 74, respectively, and they accounted for 16.85% and 40.22%, respectively. Among 184 cases with abnormal chromosome, 21 cases were azoospermia (11. 41%) and 23 cases were oligospermia (12.50%). 96 cases were recurrent spontaneous abortion and multiple fetal death during pregnancy (52.17%). Delivery of terata was 23 (12.50%), mental retardation and abnormal development were 21 (11.41%). Conclusions:Chromosome abnormity is one of the important factors in patients with infertility. Chromosome examination should be performed to exclude the possibility of chromosome abnormity in patients with obstinate infertility.关键词
染色体/不孕不育/自然流产Key words
Chromosome/ Infertility/ Abortion分类
医药卫生引用本文复制引用
张璘,张晓红,任梅宏,宋桂宁,王建六..1624例不孕不育患者中染色体核型异常184例分析[J].实用妇产科杂志,2011,27(8):607-611,5.基金项目
北京大学人民医院发展基金(RDP2008-10) （RDP2008-10）
