实用妇产科杂志2011，Vol.27Issue(8)：612-615,4.
高危因素对葡萄胎后恶变影响的临床分析
Effect of High Risk Factors on Postmolar Canceration
摘要
Abstract
Objective:To evaluate the effects of high risk factors on postmolar canceration. Methods:The clinical features of postmolar gestational trophoblastic neoplasia (GTN) with and without high risk factors were compared and analyzed. Results:Among the 72 postmolar GTN patients, the number of patients with and without high risk factors was 57 and 15, respectively. Malignant transformation rate in patients with former hydatidiform mole combined with high risk factors was significantly higher than patients without high risk factors (P<0.05). The interval between antecedent pregnancies and postmolar GTN had statistically significant differences between the patients with and without high risk factors (P<0.05). However, though the clinical symptoms in patients with high risk factors were more than that in patients without high risk factors (except vaginal bleeding) .there was no significant difference(P>0. 05). The distribution of postmolar GTN stages was no significant difference between the two groups (P>0.05) while the prognosis score did (P< 0. 05). There was no significant difference in remission rate between the two groups when patients accepted initial therapy of MTX. However, when using ACTD, there was still no statistical differences (P>0. 05). Conclusions:The high risk factors should be estimated exactly for the patients with hydatidiform mole. In addition , the prophylactic chemotherapy and surgery should be carried out on time. The patients can be estimated exactly and given the best chemotherapy methods, course and surgery time via combing with the high risk factors, FIGO stage and the modified WHO prognostic index score system together. Taking seriously to the patients with high risk factors will be helpful for the therapy of postmolar GTN.关键词
葡萄胎/恶变/高危因素/妊娠滋养细胞肿瘤Key words
Hydatidiform mole/ Canceration/ High risk factor/ Gestational trophoblastic neoplasia分类
医药卫生引用本文复制引用
潘丹,钱建华..高危因素对葡萄胎后恶变影响的临床分析[J].实用妇产科杂志,2011,27(8):612-615,4.基金项目
国家自然科学基金批准项目(T20090718),浙江省自然科学基金资助项目(J20091445),浙江省重大科技专项和优先主题项目(I20100055) （T20090718）
