针刺研究2011，Vol.36Issue(4)：302-306,312,6.
近十年针刺治疗支气管哮喘的临床及实验研究现状
Survey of Clinical and Experimental Researches on Mechanisms of Acupuncture Treatment of Bronchial Asthma
摘要
Abstract
In the present paper, the authors review the development of experimental and clinical studies on acupuncture treatment of bronchial asthma in recent 10 years. Regarding clinical studies, results showed that acupuncture could 1) regulate cardiac-pulmonary function; and 2) adjust immune state and relieve inflammatory reactions in bronchial asthma patients. Animal experiments showed that acupuncture could function in 1) improving pulmonary function; 2) reducing accumulation of the peripheral eosinophile granulocytes (EOS), relieving the infiltration of inflammatory cells in the air-passage mucosa and promoting the apop-tosis of EOS in the lung and air-passages; 3) down-regulating the expression of air-passage remodeling-related protein insulin growth factor-1 ; 4) suppressing the secretion of tumor necrosis factor and endothelin; 5) attenuating allergic reaction; 6) regulating neuroendocrine activity; and 7) modulating intracellular second messenger activities. However, rigorous clinical study design is not enough, so that the reliability of the results is limited. In spite of many indicators of animal experiments have been selected, but their correlations are not in close association, resulting in poor complementation and mutual identification of the acquired findings. For this reason, its clinical efficacies need to be researched further according to principles of evidence-based medicine.关键词
针刺客/支气管哮喘/临床研究/实验研究Key words
Acupuncture therapy/Bronchial asthma/Clinical studies/Experimental studies分类
医药卫生引用本文复制引用
谭程,赵吉平,张昶..近十年针刺治疗支气管哮喘的临床及实验研究现状[J].针刺研究,2011,36(4):302-306,312,6.基金项目
国家重点基础研究发展计划("973"计划)(2009 CB 522708) （"973"计划）
