中国当代儿科杂志2011，Vol.13Issue(9)：718-721,4.
儿童全血细胞减少的临床特点和病因诊断
Clinical features and etiological spectrum in children with pancytopenia
吴珺
1程翼飞 1张乐萍 1刘桂兰 1陆爱东 1贾月萍 1王彬1
作者信息
- 1. 北京大学人民医院儿科,北京,100044
- 折叠
摘要
Abstract
Objective To study the clinical features and etiological spectrum of pancytopenia in children. Methods The clinical data of 174 children with pancytopenia between September 2003 and January 2010 were retrospectively reviewed. Results Pale face was the most common clinical manifestation (147 cases, 84. 5% ) , followed by bleeding (87 cases, 50.0% ) and fever (41 cases, 23.6% ). Mild to moderate anemia, severe thrombocytopenia and mild leucopenia were common in complete blood count. Of the 174 children, pancytopenia was attributed to hematopoietic system diseases in 1SS cases (89.1% ) and non-hematopoietic system diseases (virus infections, systemic lupus erythematosus,hypersplenism and neuroblastoma) in 6 cases (3.4%). Aplastic anemia (91 cases, 52.3%) was the most common cause of pancytopenia, followed by myelodysplastic syndrome (37 cases, 21. 3% ), acute leukemia and other hematological tumours (11 cases, 6.3%) and hemophagocytic syndrome (6 cases, 3. 4%). The cause of pancytopenia was not identified in 13 cases (7.3%). Conclusions Anemia, bleeding and fever are the main clinical manifestations of pancytopenia in children. Pancytopenia is mostly caused by aplastic anemia in children. Myelodysplastic syndrome, hematological tumours and hemophagocytic syndrome are also the common causes.关键词
全血细胞减少/病因/临床特点/儿童Key words
Pancytopenia/ Etiology/ Clinical feature/ Child分类
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吴珺
,程翼飞,张乐萍,刘桂兰,陆爱东,贾月萍,王彬..儿童全血细胞减少的临床特点和病因诊断[J].中国当代儿科杂志,2011,13(9):718-721,4.
