中国实验动物学报2011，Vol.19Issue(4)：297-300,4.DOI:10.3969/j.issn.1005-4847.2011.04.006
球结膜下注射不同浓度消旋山莨菪碱液对雏鸡形觉剥夺近视眼轴的影响
Effects of subconjunctivally injected raceanisodamine on the axial length of chick form-deprived myopia
摘要
Abstract
Objective To investigate the effect of reacanisodamine at different concentrations on the axial length of chick form-deprived myopia. Methods Sixty 3-day old chickens were occluded the right eye with a semitransparent plastic film and randomly divided into 6 groups. Four groups were subconjunctivally injected on the right eye every 2 days for 4 times with 50 μL reacanisodamine solution at different concentrations: 0. 05% , 0. 1% , 1% ,and 2. 5% (n = 10 in each group) , respectively. The two control groups included the NS-treated form-deprived (FD) chickens treated with saline injection as the same procedure described above (n = 10) , and FD chickens with no intervention (n = 10). The effect of the drug on the axial length was evaluated at 8 days after the drug-treatment. Results The difference of axial length between the right and left eyes in the 2. 5% raceanisodamine group was significantly smaller than that of the low concentration groups and control groups. Conclusions Raceanisodamine has certain inhibitory effect on the elongation of axial length of FD chickens in a concentration-dependent manner without toxic effects.关键词
球结膜下注射/消旋山莨菪碱/雏鸡形觉剥夺近视/眼轴Key words
Raceanisodamine/ Axial length, eye/ Chicken form-deprived myopia/ Subconjunctival injection分类
生物科学引用本文复制引用
杨颖,李涛,陈志,周行涛..球结膜下注射不同浓度消旋山莨菪碱液对雏鸡形觉剥夺近视眼轴的影响[J].中国实验动物学报,2011,19(4):297-300,4.基金项目
上海市科委2009年度“创新行动计划”生物化学领域重点定向项目(编号:09DZ1906700). （编号:09DZ1906700）
