中国实验动物学报2011，Vol.19Issue(4)：336-338,3.DOI:10.3969/j.issn.1005-4847.2011.04.014
MicroPET观察姜黄素对APPswe/PS1dE9双转基因小鼠脑葡萄糖代谢的影响
MicroPET observation of the effect of curcumin on cerebral glucose metabolism in APPswe/PS1dE9 double transgenic mice
摘要
Abstract
Objective To observe the status of cerebral glucose metabolism in normal control group mice, APP/ PS1 double transgenic mice of model group and curcumin treatment group by 18F-FDG microPET. Methods APP/PS1 dtg mice from the model group, curcumin treatment group,and normal C57BL/6J mice with the same background were randomly selected ( age: 6 months; n = 3 ) for microPET study. Each mouse was anesthetized using 2% isoflurane and was injected through a tail vein with 14. 8-16. 5 MBq "F-FDG as a bolus. After 45-minute of "F-FDG uptake period, PET scans were performed for 10-min. Calculate and compare "F-FDG uptake rate per gram tissue of the whole brain ( except cerebellum) in the mice of different groups. Results Cerebral "F-FDG uptake rate per gram tissue of curcumin treatment group mice is higher than both the normal control group and model group mice. Conclusions Curcumin can increase cerebral "F-FDG uptake and " F-FDG uptake rate per gram tissue. Curcumin may play a neuroprotective role through an influence to cerebral glucose metabolism.关键词
18氟-脱氧葡萄糖/脑葡萄糖代谢/姜黄素/APPswe/PS1 dE9双转基因小鼠Key words
microPET/18F-FDG/Cerebral glucose metabolism/Curcumin/APPswe/PS1dE9 double transgenic mice分类
生物科学引用本文复制引用
王虹,高凯,李瑞晟,任映,朱志慧,孙海芸,杨金铎,王蓬文..MicroPET观察姜黄素对APPswe/PS1dE9双转基因小鼠脑葡萄糖代谢的影响[J].中国实验动物学报,2011,19(4):336-338,3.基金项目
北京市自然基金资助项目(No.7092057),国家自然基金资助项目(No.81073076). （No.7092057）
