中国美容医学2011，Vol.20Issue(z5)：36-37,2.
缬沙坦预处理对乳鼠心肌细胞缺氧/复氧损伤的保护作用
Protective effects of Valsartan pretreatment on hypoxia/reoxygen injury in neonatal SD rat cardiomyocytes
摘要
Abstract
Objective;To observe protective action of Valsartan pretreatment on hypoxia/reoxygen injury in neonatal SD rat cardiomyocytes and to investigate the mechanism. Methods: To establish a model for primary culture of cardiomyocytes injuried by hypoxia/reoxygen. The morphology of cardiomyocytes was observed,and cardiomyocytes fraction surviving were measured,and the activity of lactate dehydrogenase (LDH) * malondialdehyde (MDA),superoxide dismutase (SOD) were assayed. Results: Valsartan pretreatment on hypoxia/reoxygen injury in neonatal SD rat cardiomyocytes inhance cardiomyocytes fraction surviving (P<0. 05), and decrease the activity of LDH, content of MDA and improve the acivity of SOD in the injuried myocytes (P<0. 05). Conclusion:Valsartan pretreatment can prevent the cultured cardiac myocytes during hypoxia/reoxygenation injury obviously. The mechanisms may be as below:Valsartan pretreatment can stabilized the membrane of myocardium, restrict oxygen free radical injury in cardiac myocyte during hypoxia/reoxygenation injury.关键词
缬沙坦/心肌细胞/缺氧复氧/预处理Key words
Valsartan/cultured cardiac myocyte/hypoxia/reoxygenation injury/ pretreatment分类
医药卫生引用本文复制引用
王亮,戴振华,陈鹏..缬沙坦预处理对乳鼠心肌细胞缺氧/复氧损伤的保护作用[J].中国美容医学,2011,20(z5):36-37,2.基金项目
南京医科大学科技发展基金项目资助(NJ03048). （NJ03048）
