昆虫学报2011，Vol.54Issue(8)：918-926,9.
家蚕细胞色素P450基因的研究进展
Research advances in cytochrome P450 genes in the silkworm, Bombyx mori
摘要
Abstract
The cytochrome P450 monooxygenases ( P450s, C Yps) constitute a large and complex superfamily of heme-thiolate proteins, which are responsible for the oxidative metabolism of structurally diverse endogenous and exogenous compounds. In this review, recent progress in Bombyx mori P450 diversity, multiple functions, genomic distribution, intron-exon organization and the evolutionary relationships to P450s from Drosophila melanogaster is summarized, and the proposals of B. Mori P450 study are also put forward. In the silkworm, the paralog count for P450s is lower than those found in other scavengers and omnivorous phytophagous insects, but substantially higher than that observed in Apis mellifera. The distribution of B. Mori P450s in the genome indicates that most of them are tandem arranged on chromosomes. There is a relatively good correlation between intron-exon organization and phylogenetic relationship among these multiple P450s. Comparison of the P450s from B. Mori to the P450s from D. Melanogaster reveals that there are 10 pairs of recognizable orthologs and the P450s in CYP3 and CYP4 clans are present with species-specific expansion. These diverse P450s have been demonstrated to be associated with growth and development, tolerance to fluoride and resistance to insecticides. The silkworm is a good representative insect of the order Lepidoptera, and it is so expected that it might found theoretical basis and model system for developmental regulation and resistance management of other insects, especially for lepidopteran insects, with the further study of B. Mori P450s.关键词
家蚕/细胞色素P450/多样性/进化/模式昆虫Key words
Silkworm/ cytochrome P450 monooxygenase/ diversity/ evolutionary relationship/model insect分类
生物科学引用本文复制引用
艾均文,薛宏,何行健,孟繁利,朱勇,向仲怀..家蚕细胞色素P450基因的研究进展[J].昆虫学报,2011,54(8):918-926,9.基金项目
国家“863”计划项目(2006AA10A117) （2006AA10A117）
现代农业(蚕桑)产业技术体系建设专项(CARS-22) （蚕桑）
湖南省科学技术厅项目(2010NK3050) （2010NK3050）
湖南省农业厅项目(2008-01-05) （2008-01-05）
