癌变·畸变·突变2011，Vol.23Issue(5)：362-366,5.DOI:10.3969/j.issn.1004-616x.2011.05.009
食管癌中环氧化酶-2表达与临床病理特征相关关系的Meta分析
Relationship between COX-2 expression and clinicopathologic features of esophageal cancer:a Meta-analysis of case-control studies
摘要
Abstract
OBJECTIVE: To explore the association between COX-2 expression in human esophageal cancer and its clinicopathologic characteristic* of esophageal cancer. METHODS: Published studies were searched in the CBMdisc(1978-20U), CNKI(1979-2010), VIP( 1989-2010) database, CMA Digital Periodicals( 1998-2010), other relevant journals were manually searched lo identify all the related case-control studies in mainland China. The quality of the included studies was assessed. Cochrane Collaboration' s Software Revman 5.0.2 was utilized lo test the heterogeneity, the overall effect and the publication bias of the combined studies as well. RESULTS: Seven siudies were included. For the positive rate of COX-2 expression, significant difference was tested between esophageal cancer and normal esophageal lissues[OR=31.44, 95%CI( 10.47, 94.38)]. In addition, cell differentiation G1+C2 vs. Cell differentiation G3 revealed significant difference[OR=3.60. 95%CI(1.63, 7.99)]. However, there was not any significant difference shown in terms of gender, age, depth of invasion, lymph node metastasis, of which the overall effect were 1.56(0.61, 3.98), 0.59(0.27, 1.30), 1.21(0.49, 2.98), 1.47 (0.38, 5.64), respectively. CONCLUSION: According to the currently available national evidence, higher COX-2 expression may be associated with esophageal cancer and cell differentiation.关键词
食管肿瘤/环氧化酶-2/Meta分析Key words
esophageal cancer/ cyclooxygenase-2/ Meta-analysis分类
医药卫生引用本文复制引用
蔡尔慧,蔡绍先,陈玮莹,高永鑫,徐小华,杜忠仁,陈梅兰,李克..食管癌中环氧化酶-2表达与临床病理特征相关关系的Meta分析[J].癌变·畸变·突变,2011,23(5):362-366,5.基金项目
广东省科技计划基金项目(2010B 31600025) （2010B 31600025）
广东省大学生创新实验项目(20105710) （20105710）
汕头大学医学院杰出大学生科研基金项目(20105710) （20105710）
