癌变·畸变·突变2011，Vol.23Issue(5)：380-383,4.DOI:10.3969/j.issn.1004-616x.2011.05.014
透明质酸钠对SD大鼠致畸敏感期的毒性试验
Study of the sodium hyaluronate toxicity on SD rats in sensitive period of teratogenesis
彭亮 1傅伟忠 1王彦武 1覃辉艳 1姚思宇 1梁慧莉 1何励1
作者信息
- 1. 广西自治区疾病预防控制中心,广西,南宁,530028
- 折叠
摘要
Abstract
OBJECTIVE: To explore the toxicity of sodium hyaluronate on SD rate in sensitive period of teratogenesis. METHODS: Pregnant rats were divided randomly into five groups, three sodium hyaluronate groups (1 333, 667 and 333 mg/kg), one negative control given deionized water, and one positive control given Aspirin (250 mg/kg>. There were at least 12 pregnant rats in each group. During the sensitive period of laratogenesis (the 7th to 16th day of gestation), the pregnant rats of each group were given test sample orally once a day for ten days. On the 20th day of gestation, the pregnant rals were sacrificed. Emhryonic and fetal development were evaluated, appearance, viscesal and skeletal abnormalities were observed. RESULTS: In sodium hyaluronate groups, (he weight of pregnant rats and uterus including fetuses, living fetus rate, dead fetua rale, body weight, length of body and tail of fetuses were not significantly different from negative control. No abnormality of skeleton, organ and body was identified in fetuses of groups treated with sodium hyaluronaie. CONCLUSION: At dosages used in this study, sodium hyaluronate had neilher maternal tosiciry nor teratogenecity in pregnant SD rats.关键词
透明质酸钠/SD大鼠/致畸毒性Key words
sodium hyaluronate /SD rates teratogenedty分类
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彭亮,傅伟忠,王彦武,覃辉艳,姚思宇,梁慧莉,何励..透明质酸钠对SD大鼠致畸敏感期的毒性试验[J].癌变·畸变·突变,2011,23(5):380-383,4.
