现代妇产科进展2011，Vol.20Issue(8)：604-609,6.
MDR1基因甲基化与新疆维吾尔族、汉族宫颈癌新辅助化疗疗效的相关性
Methylation of MDR1 gene in promoter region is related with the effect of neoadjuvant chemotherapy on cervical carcinoma in Uigur and Han of Xinjiang.
摘要
Abstract
Objective:To investigate the correlation between methylation of MDR1 gene in promoter region and the effect of neoadjuvant chemotherapy on cervical carcinoma in Uigur and Han of xinjiang. Method: Mass ARRY EpiTYPER DNA methylation analyzing technique was used to detect the 22 CPG sites methylation status of MDR1 gene promoter region which in groups before and after NACT of cervical carcinoma and normal group. Results: (1) The average methylation rate in cervical carcinoma group was lower than that in the normal group, except CpG-11, CpG-12,13, CpG-23, CpG-30 of Han and CpG-5, CpG-11, CpG-12,13, CpG-19,20, CpG-22,CpG-23,CpG-25,26,27 of Uigur (P<0.05). (2) We found the average methylation rate of CpG-5, CpG-7, CpG-8, CpG-19,20, CpG-23, CpG-25,26,27 have significant difference in Uigur and Han in before NACT group (P<0.05). (3)The average methylation rate in after NACT group was lower than that in before NACT group,CpG-7,CpG-8,CpG-12,13,CpG-18, CpG-23 of Han and CpG-7,CpG-8,CpG-12,13,CpG-18,CpG-19,20,CpG-25,26,27,CpG-30 of Uigur significant difference were found(P<0.05). (4)The average methylation rate in drug resistance group was lower than that in sensitive group,CpG-2,3,4 of Han and CpG-6,CpG-7, CpG-8,CpG-12,13 CpG-19,20 CpG-23 CpG-30 of Uigur significant difference was found(P< 0.05). Conclusion: There is closely correlation between parts CPG island abnormal methylation of MDR1 gene in promoter region and the effect of neoadjuvant chemotherapy on cervical carcinoma, and some differences were also found in Uigur and Han.关键词
MDR1基因/甲基化/宫颈癌/新辅助化疗/维吾尔族/汉族Key words
MDR1 gene/Methylation/Cervical carcinoma/Neoadjuvant chemotherapy/Uigur/Han分类
医药卫生引用本文复制引用
李文婷,王英红,高丽敏..MDR1基因甲基化与新疆维吾尔族、汉族宫颈癌新辅助化疗疗效的相关性[J].现代妇产科进展,2011,20(8):604-609,6.基金项目
石河子大学重大攻关专项基金项目(No:gxji2008-zdgg07) （No:gxji2008-zdgg07）
