中国医科大学学报2011，Vol.40Issue(8)：729-731,3.DOI:21-1227/R.20110726.1656.009
血清蛋白电泳在类风湿性关节炎诊治中的应用
Application of Serum Protein Electrophoresis in Rheumatoid Arthritis
摘要
Abstract
Objective To analyse the role and clinical significance of serum protein electrophoresis in rheumatoid arthritis (RA). Methods 186 rheumatoid arthritis cases (study group) and 75 healthy adults underwent serum protein electrophoresis (control group). Serum level of total protein,albumin,globulin,rheumatoid factor(RF),C-reactive protein(CRP) and immunoglobulin (IgA,IgM,IgG) were detected at the same time. The 186 RA patients were followed up for one year and were divided into active stage group and unactive stage group. Serum protein electrophoresis results and immunoglobulin levels were compared between the two groups. Results Compared with the control group,the study group had significantly lower albumin level and significantly higher α1 globulin,α2 globulin and γglobulin levels(P< 0.01). Serum RF,CRP and immunoglobulin levels in the study group were significantly higher than those in the control group (P < 0.01). During the follow-up period,serum albumin was significantly reduced in RA patients at active stage,while serum α1 globulin,α2 globulin,γ globulin and immunoglobulin levels were significantly increased (P < 0.05 or P < 0.01). Conclusion Combination of serum protein electrophoresis and serum protein measurement in RA patients is very important for the diagnosis,treatment,monitoring and prognosis judgment.关键词
血清蛋白电泳/血清蛋白/血清免疫球蛋白/类风湿性关节炎Key words
serum protein electrophoresis/ serum protein/ serum immunoglobulin/ rheumatoid arthritis分类
医药卫生引用本文复制引用
王金行,周立平,阎莉莉,张丽霞..血清蛋白电泳在类风湿性关节炎诊治中的应用[J].中国医科大学学报,2011,40(8):729-731,3.基金项目
辽宁省教育厅高校科研计划(L2010695) （L2010695）
