中国医科大学学报2011，Vol.40Issue(8)：735-737,740,4.DOI:21-1227/R.20110726.1657.011
脑膜瘤手术后复发因素
Risk Factors of Intracranial Meningioma Relapse after Operation
摘要
Abstract
Objective To investigate the risk factors of intracranial meningioraa relapse after gross total resection. Methods 162 menin-gioma patients who underwent gross total resection under the microscope,excluding those with convex tumors,were analyzed retrospectively and followed up for at least 3 years. Unifactor and multifactor Cox regression models were performed to analyze the relationships between the post-op tumor relapse and clinical characters of the patients (sex,age,tumor size,tumor shape),pathological grade of tumor,expressions of some immunohistochemical indicators (Ki-67,AR,ER,PR). Results There are 53 cases of recurrent meningiomas within the 5-year follow-up. The recurrent rate is about 32.7 percent. Immunohistochemical staining results indicated that expressions of AR,ER,PR and Ki-67 were positive in some tumor cell nucleuses. Cox regression analysis revealed that tumor size,tumor shape,pathological grade and Ki-67 expression were significantly correlated with the tumor relapse (P < 0.05). Conclusion Our results demonstrated high recurrent rate of meningiomas after gross total resection. Tumor diameter exceeding 5 cm, irregular tumor shape, pathological grade Ⅱ and Ⅲ and positive expression of Ki-67 were the risk factors of post-op meningioma relapse. The recurrent rate increased along with the follow-up time.关键词
脑膜瘤/手术/复发Key words
meningioma/ operation/ relapse分类
医药卫生引用本文复制引用
陶英群,梁国标,李智勇,王运杰,吴安华,王海龙,卢亦成,胡国汉,刘震洋..脑膜瘤手术后复发因素[J].中国医科大学学报,2011,40(8):735-737,740,4.基金项目
辽宁省科技攻关课题(2008225009-9) （2008225009-9）
上海市科学技术委员会科研计划项目(08431900400) （08431900400）
