中国中西医结合杂志2011，Vol.31Issue(9)：1213-1215,3.
五酯胶囊在肾移植术后的临床应用研究
Study on the Clinical Application of Wuzhi Capsule after Renal Transplantation
谢申平 1眭维国 1晏强 1陈怀周 1车文体 1郭骏军 1邹贵勉 1梁桂荣 1邹和群 2马井生1
作者信息
- 1. 中国人民解放军第181中心医院全军肾移植与透析中心(广西桂林541002)
- 2. 南方医科大学附属第三医院肾脏内科(广州510630)
- 折叠
摘要
Abstract
Objective To study the protection of Gan by using deoxyschizandrin (Wuzhi Capsule, WC) in the renal transplantation recipients while increasing the blood concentration of tacrolimus (Tac). Methods Seventy-three renal transplant recipients were randomly assigned to two groups, i. e., 35 in the WC group and 38 in the control group. All patients received Tac + MMF + Pred triple immunosuppressive therapy. WC was additionally given to patients in the WC group. One year was taken as one therapeutic course. Changes of the blood concentration of Tac were detected one week, 1,3,6, and 12 months after medication in the two groups using mi-croparticle enzyme immune assay (MEIA). Meanwhile, the liver and kidney functions, and the blood glucose were tested. Results One week after the application of WC, the blood Tac concentration increased 67. 2% aver-agely. During the 1 -12 months of WC treatment, the Tac dosage was significantly lower in the WC group than in the control group (P<0.01). There was no significant difference in the liver and renal functions, or the blood glucose levels between the two groups ( P>0. 05). Conclusion WC could significantly increase the blood Tac concentration of renal transplant recipients, reduce their Tac dosages, with no obvious adverse reaction.关键词
五酯胶囊/他克莫司/血药浓度/肾移植Key words
Wuzhi Capsule/ tacrolimus/ blood concentration/ renal transplantation引用本文复制引用
谢申平,眭维国,晏强,陈怀周,车文体,郭骏军,邹贵勉,梁桂荣,邹和群,马井生..五酯胶囊在肾移植术后的临床应用研究[J].中国中西医结合杂志,2011,31(9):1213-1215,3.
