摘要
Abstract
Objective To study the clinical characteristics of hepatitis-associated aplastic anemia (HAAA). Methods A retrospective analysis was conducted among 8 cases of established HAAA in light of the clinical and laboratory findings and the patient outcomes. Results Serum samples from 8 patients with HAAA were tested for the antibodies to hepatitis viruses A, B, C, D, E and CMV, and 7 patients showed negative serological results while only one was positive for HBsAg. The percentage of CD4+ cells was significantly lowered while the percentage of CD8+ cells significantly increased to result in a lowered ratio of CD4+/CD8+ cells in these HAAA patients. A shift in the Thl/Th2 and Tcl/Tc2 balance to a Thl and Tel dominance was noted. The percentage of Treg cells was obviously decreased. Significant increments were found in the serum levels of interleukin-2, THF-a and interferon-y. Three of the patients responded to immunosuppresssive treatment; one patient achieved a complete remission, two had a partial remisson, and five failed to respond to the therapy and died. Conclusion HAAA may not have an obvious association with viral " infections as by hepatitis virus A, B, C, D, or E, and its pathogenesis often involves abnormalities of the T cell immunity. Commonly with a poor prognosis, HAAA is associated with a high mortality rate.关键词
肝炎/再生障碍性贫血/临床分析Key words
anemia aplastic/ hepatitis, viral/ clinical analysis分类
医药卫生
