中国药房2011，Vol.22Issue(29)：2740-2743,4.
酮康唑固体分散体及共研磨物的制备及其体外溶出作用研究
Study on the Preparation and in Vitro Dissolution of Ketoconazole Solid Dispersion and Cogrinding Mixture
摘要
Abstract
OBJECTIVE: To prepare Ketoconazole solid dispersions and cogrinding mixture, and to investigate dissolution rate in vitro. METHODS: Ketoconazole solid dispersion was prepared by melting or solvent evaporation methods using PEG, PVP, F68 as carrier materials with different proportion of drugs to carrier (1:1, 1:3, 1:5, 1:10). Ketoconazole cogrinding mixture was prepared with different proportion of drugs to L-HPC (1:0.5, 1:1, 1:1.5). The in vitro dissolution rate of Ketoconazole solid dispersions and cogrinding mixture were tested and compared with that of ketoconazole raw material. RESULTS: Compared with raw material, drug-loaded solid dispersion and cogrinding mixture could significantly improve the dissolution rate of ketoconazole with the proportion of carriers increased. Within 20 min, all dissolution rates of solid dispersion (1:10) and cogrinding mixture (1:15) were above 90% while that of raw material was lower than 50%. CONCLUSION: Solid dispersion technology and cogrinding method can significantly increase the dissolution rate of ketoconazole.关键词
酮康唑/固体分散体/共研磨物/制备/体外溶出作用Key words
Ketoconazole/Solid dispersion/Cogrinding mixture/Preparation/In vitro dissolution分类
医药卫生引用本文复制引用
秦凌浩,王晓明,胡巧红,冯贝贝..酮康唑固体分散体及共研磨物的制备及其体外溶出作用研究[J].中国药房,2011,22(29):2740-2743,4.
