RP-HPLC法测定人血浆中齐拉西酮的浓度△OACSCDCSTPCD
Determination of Ziprasidone in Human Plasma by RP-HPLC
目的:建立测定人血浆中齐拉西酮浓度的方法.方法:采用反相高相液相色谱法,色谱柱为美国Diamonsil C18,流动相为乙腈:甲醇:缓冲液(三乙胺5mL加入水1 000mL中,冰醋酸调节pH值至3.2)=28:12:60,流速为1.3 mL·min-1,检测波长为254nm,进样量为20μL.结果:齐拉西酮血药浓度在0.022～2.816 μg·mL-1范围内线性关系良好(r=0.999 2,n=8),定量下限为0.022μg·mL-1.结论:本…查看全部>>
OBJECTIVE: To establish the method for the determination of ziprasidone in human plasma ? METHODS: RP-HPLC method was adopted. The determination was performed on Diamonsil? C18(250 mm×4.6 mm, 5μm) with mobile phase consisted of acetonitrile: methanol: buffer (triethylamine 5 mL added into water 1 000 mL, pH value adjusted to 3.2 using glacial acetic acid)(28:12:60) at the flow rate of 1.3 mL-min-1.The detection wavelength was set at 254 nm and injectio…查看全部>>
黄洪勇;吕路线;王金宝;钱东丽;师天元
新乡医学院第二附属医院,新乡市453002新乡医学院第二附属医院,新乡市453002新乡医学院第二附属医院,新乡市453002新乡医学院第二附属医院,新乡市453002河南省生物精神病学重点实验室,新乡市453002
医药卫生
反相高效液相色谱法齐拉西酮血药浓度药动学
RP-HPLCZiprasidonePlasma concentrationPharmacokinetics
《中国药房》 2011 (34)
3196-3198,3
2008年河南省高校科技创新团队支持计划项目(20081RT-STHN008)
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