实用妇产科杂志2011，Vol.27Issue(8)：623-626,4.
同步放化疗与新辅助化疗术前用药在局部中晚期宫颈癌治疗中的临床疗效评价
Effects of Concurrent Chemoradiation and Neoadjuvant Chemotherapy on Local Advanced Cervical Cancer
钟亚娟 1张蔚 1易跃雄 1周琦 1张文婷 1李兰玉 1郭婉茹1
作者信息
摘要
Abstract
Objective:To determine the effects of concurrent chemoradiation and neoadjuvant chemotherapy before operation on local advanced cervical cancer. Methods: We retrospectively analyzed the clinical data of 42 female patients with stage I B2 - || B cervical cancer from March 2002 to March 2005 in our hospital. According to preoperative treatments, the patients were divided into two groups, group 1 preoperatively treated by concurrent chemoradiation (the experimental group), group 2 treated by neoadjuvant chemotherapy(the control group) · The schedule was the same in two groups. For squamous carcinoma: cisplatin( DDP) plus bleomycin were used, and for adenocarcinoma:cisplatin + 5-fluorouracil(5-Fu) + mitomycin(MMC) were used. Group 1 was accompanied by intracavity brachytherapy. Operation was done after concurrent chemoradiation and neoadjuvant chemotherapy. The recent curative effects, the rate of radical hysterectomy and the condition of incision margin, adverse reaction and the long term effect (the one-year, three-year and the five-year survival rate) were observed in two groups. Results:There was no significant differences in the recent curative effect between the two groups (P>0.05). The operative rate and the negative rate of incision margin were significantly higher in group 1 than in group 2( P<0. 01). No obvious difference of blood and gastrointestinal side effects were found between the two groups (P>0. 05). There was highly statistical difference in late complication about radiation proctitis and cystitis between two groups (P<0.01). The 1 and 3 years survival rate in two groups was no statistical difference (P>0.05), while the five-year survival rate was higher in group 1 than in group 2( P<0.05). Conclusions:Preoperative concurrent chemoradiation is better than neoadjuvant chemotherapy in the treatment of local advanced cervical cancer.关键词
同步放化疗/新辅助化疗/宫颈癌/近期疗效/远期疗效Key words
Concurrent chemoradiation/ Neoadjuvant chemotherapy/ Cervical cancer/ Recent curative effect/ Long term effect分类
医药卫生引用本文复制引用
钟亚娟,张蔚,易跃雄,周琦,张文婷,李兰玉,郭婉茹..同步放化疗与新辅助化疗术前用药在局部中晚期宫颈癌治疗中的临床疗效评价[J].实用妇产科杂志,2011,27(8):623-626,4.
