实用医学杂志2011，Vol.27Issue(19)：3505-3507,3.DOI:10.3969/j.issn.1006-5725.2011.19.021
甲状腺球蛋白测定和131I-全身显像在综合治疗分化型甲状腺癌随访中的价值
The clinical value of serum thyroglobulin combined with Iodine-131 whole body scanning in the follow-up of differentiated thyroid cancer after thyroid ablation
摘要
Abstract
Objective To investigate the clinical value of serum thyroglobulin (Tg) measurements combined with Iodine-131 (131I) whole body scans (WBS) in the follow-up of differentiated thyroid carcinoma (DTC) after thyroid ablation. Methods Fifty-five patients were enrolled in the study. A diagnostic 131I-WBS was performed 48h after administration of 111 ~ 185 MBq 131I in patients with post-thyroidectomy and 131I ablated treatment. Subsequently, therapeutic 131I-WBS were performed 5 ~ 7 days after administration of 3.7 ~ 5.55 GBq 131I. Serum Tg and anti-thyroglobulin autoantibody were measured in all patients. Results In 11 of 24 patients (45.8%) with relapsed or metastatic differentiated thyroid carcinoma, the serum Tg values increased over normal range. In 21 patients (87.5%), the results of 131I-WBS were positive. Among these patients, both abnormally radioactive uptake in 131I-WBS and elevation of serum Tg were found in only 8 patients (33.3%). Conclusions Routine serum Tg measurement and 131I-WBS in patients with DTC after thyroidectomy is essential. It is of great clinical value in early detecting metastatic nidus, optimizing the treatment protocol and evaluating the curative effect.关键词
甲状腺肿瘤/放射疗法/放射性核素显像/甲状腺球蛋白Key words
Thyroid neoplasms / Radiotherapy/ Radionuclide imaging / Thyroglobulin引用本文复制引用
廖宁..甲状腺球蛋白测定和131I-全身显像在综合治疗分化型甲状腺癌随访中的价值[J].实用医学杂志,2011,27(19):3505-3507,3.基金项目
广西医疗卫生重点科研课题(编号:重2000985) （编号:重2000985）
