江苏大学学报（医学版）2011，Vol.21Issue(5)：423-427,5.
胰腺癌组织中Smad4、上皮型钙黏蛋白及β-连环蛋白的表达及临床意义
Expression and clinical significance of Smad4、E-cadherin and β-catenin in pancreatic cancer
摘要
Abstract
Objective: To elucidate the mechanism of pancreatic cancer invasion and metastasis; and the expression of Smad4, E-cadherin and p-catenin in pancreatic cancer tissue was going to observe. Methods : The expression of Smad4, E-cadherin and p-catenin protein in a constructed tissue array was analyzed by immunohistochemistry and cross referencing of clinicopathologic data. Results: In tissue samples from 88 pancreatic cancer cases, positive immunoreactivity of Smad4,E-cadherin and p-catenin expressions, which were 55.7% (49/88) ,51. 1% (45/88) and 60. 2% (53/88),respectively, were significantly lower than those in normal pancreatic tissue (P <0. 01). There was no significant difference between positive immunoreactivity of Smad4, E-cadherin and p-catenin expression with clinicopathologic data of pancreatic cancer patients including sexuality, age, tumor site and tumor size (P > 0. 05). Positive immunoreactivity of Smad4, E-cadherin and p-catenin expressions were significant correlated with tumor histopathological grade, clinical TNM stages and lymphnode metastasis ( P < 0. 01). There was statistically positive correlation a-mong Smad4, E-cadherin and p-catenin expressions in pancreatic cancer tissue (P <0. 01). There was statistically correlation between positive immunoreactivity of Smad4, E-cadherin and p-catenin expression with survival time by Kaplan-Meier analysis. Conclusion: Smad4, E-cadherin and p-catenin were lowly co-expressed in pancreatic cancer tissue. Smad4 may inhibit the progression of pancreatic cancer through reducing E-cadherin and p-catenin production in pancreatic cancer tissue.关键词
胰腺癌/Smad4/上皮型钙黏蛋白/β-连环蛋白Key words
pancrealic cancer/ Smad4/ E-cadherin/fl-catenin分类
医药卫生引用本文复制引用
肖蔚,焦霞,赵燕,周彤敏,窦荣荣,于鸿..胰腺癌组织中Smad4、上皮型钙黏蛋白及β-连环蛋白的表达及临床意义[J].江苏大学学报（医学版）,2011,21(5):423-427,5.基金项目
南通大学自然科学基金资助项目(10Z088) （10Z088）
泰州市311工程人才基金资助项目(201036) （201036）
