军事医学2011，Vol.35Issue(10)：737-741,5.
调控性SNP与羟自由基切割谱变化值的关系研究
Study of correlation between the regulatory SNPs and changes in hydroxyl radical cleavage patterns
张志毅 1岳俊杰 2王月兰 1李北平 1谭明峰 1梁龙 1孙建中1
作者信息
- 1. 军事医学科学院生物工程研究所,北京,100071
- 2. 军事医学科学院科技部,北京,100850
- 折叠
摘要
Abstract
Objective To test the effectiveness of using a new method-hydroxyl radical cleavage pattern that is used to predict the functional non-coding region in the genome-to recognize the regulatory single nucleotide polymorphism ( rSNP ). Methods Ninety-nine rSNPs were collected from Human Gene Mutation Database( HGMD ), and their controls were all the other SNPs located in the 2 kb upstream region of genes. The forward strand and backward strand were calculated respectively. Results The changes in the hydroxyl radical cleavage pattern caused by rSNPs were statistically smaller than those by controls on the forward strand, but not so on backward strand. Conclusion This method presents statistical significance when it is used to recognize the rSNP, but the trend of rSNPs is different from that of the phenotype-associated SNP.关键词
羟自由基切割/调控性SNPKey words
hydroxyl radical cleavage/ regulatory SNP分类
生物科学引用本文复制引用
张志毅,岳俊杰,王月兰,李北平,谭明峰,梁龙,孙建中..调控性SNP与羟自由基切割谱变化值的关系研究[J].军事医学,2011,35(10):737-741,5.
