临床口腔医学杂志2011，Vol.27Issue(9)：530-532,3.DOI:10.3969/j.issn.1003-1634.2011.09.006
整合素α5β1和纤维粘连蛋白在Ⅱ型糖尿病大鼠种植体周围骨组织的表达及意义
The expression and significance of integrin α5β1 and fibronectin in osseous tissue around implant of type Ⅱ diabetic rats
王兴 1焦艳军 1孙晓军 1孟兵1
作者信息
- 1. 山西医科大学附属第一医院口腔科,山西,太原,030001
- 折叠
摘要
Abstract
Objective: To detect and compare the expression of integrin α5β1 and fibronectin (FN) in osseous tissue around implant between Type D Diabetic Rats and normal rats, and explore the possible mechanism that diabetic mellitus affect the implant osseointegration. Method: Establish the rat model of type Ⅱ diabetes, then 48 rats were divided into four groups randomly: normal implanting group (group C) > normal control group (group CO) . Diabetic implanting groups (group T), diabetic control group (group TO). The group C and group T were implanted the titanium implant near the epiphyseal end of tibia. Rats were killed after two, four and eight weeks in batches. Using immunohistochemistry method the expression of integrin α5β1 and FN were detected in osseous tissue around the implants in each group. Result: The expression of integrin α5β1 and FN in osseous tissue around the implants in group T were significantly stronger than the expression in group C in two and four weeks (P <0.05) .Eight weeks after implantation, the expression of integrin α5β1 in group T were close to that of group C, while the expression of FN in group T was significantly stronger than group C (P <0.05). Conclusion: Diabetic mellitus may weaken the implant osseointegration by changing expression of integrin α5β1 and FN in osseous tissue around the implants.关键词
糖尿病/种植体/骨结合/整合素α5β1/纤维粘连蛋白Key words
diabetes/implant/osseointegration/integrin α5β1/fibronectin分类
医药卫生引用本文复制引用
王兴,焦艳军,孙晓军,孟兵..整合素α5β1和纤维粘连蛋白在Ⅱ型糖尿病大鼠种植体周围骨组织的表达及意义[J].临床口腔医学杂志,2011,27(9):530-532,3.
