李盛华 1李玉吉 1李慎松 2邓强 1柳永明 1孔令俊 1朱换平 1廖敏捷1
作者信息
- 1. 甘肃省中医院运动创伤科,甘肃,兰州,730050
- 2. 兰州军区总医院
- 折叠
摘要
Abstract
Objective:To observe the effects of Chinese herb of promoting blood circulation to dissipate blood stasis on the levels of tumor necrosis factor alpha(TNF-a)and interleukin 6(IL-6) in serum of patients with mudslide injuries,and investigate the mechanisms of Chinese herb of promoting blood circulation to dissipate blood stasis in the treatment of mudslide injuries. Methods: Patients with mudslide injuries who were translated from Zhouqu and Chengxian to Lanzhou from 12th August 2010 were divided into two groups (group A and group B). Twenty-five patients in group A,containing 15 males and 10 females,with an average age of (39.0±3.9) years. According to AIS scoring system, 1 point in 2 cases,2 points in 3,3 points in 17 and 4 points in 3. No patients got 5 points. Based on ISS rating system, 16 cases got 16 points or less,7 cases rated between 16 and 25,only 2 cases were equal to 25 points or more. Another 25 patients were in group B,including 11 males and 14 females,with a mean age of(40.1±3.6) years;AIS score showed 3 cases got 1 point,4 got 2 points, 16 got 3 and 2 got 4 points.no patients got 5 points. Patients in group B were divided into three parts by ISS score: 15 cases (16 points or less) ;9 cases (range 16 to 25 points) and 1 case(25 points or more). All the patients accepted general physical checkup. Eight patients were treated by surgical treatment in group A (3 patients were treated with open reduction plate fixation,4 patients were treated with de-bridement BHID.and 1 patient underwent foreign body removal) and 6 cases in group B( 1 patient was treated with craniocere-bral surgery,2 patients were treated with chest surgery,and 3 patients were treated with soft tissue debridement). All the patients of two groups were treated by support treatment, detumescence treatment and preventing infection, complications. A seven days course of treatment with detumescence analgesic mixture 50 ml p.o. Bid, traumatologic cleansing liquid 20 ml ad us, ext 20 to 30 min qid to group A .continuous treatment of two courses. Using immunometric assay to determine serum levels of inflammatory cytokine TNF-α,IL-6 at the 2nd,7th, 14th days after admission. Analysis of data were done with the help of SPSS 16.0 statistic software. Results:There were no statistical differences of TNF-a,IL-6 between two groups at the second day after admission,and there were statistical differences at the /th and 14th days between two groups. I here were significant dinerences of TNF-a and IL-6 levels between the 7th day and the 2nd day,the 14th day and 2nd day after admission. Conclusion:The Chinese herb of promoting blood circulation to dissipate blood stasis can inhibit the release of inflammatory factor aftertraumatism.关键词
创伤与损伤/肿瘤坏死因子-α/白细胞介素-6/活血祛瘀剂/病例对照研究Key words
Wounds and injuries/Tumor necrosis factor-alpha/Interleukin-6/Blood act remov agents/Casecontrol studies
