实用医学杂志2011，Vol.27Issue(19)：3522-3525,4.DOI:10.3969/j.issn.1006-5725.2011.19.027
同型半胱氨酸及其代谢关键酶MTRR基因多态性与颅内动脉瘤的关系
The relationship of polymorphism of methionine synthase gene and plasma homocysteine level with intracranial aneurysm
陈盛强 1罗学港 1戴文伟 2许绍强 3孙卫文 2邓维意 2伍建伟 2李明昌 2何伟文 2陆永健2
作者信息
- 1. 410013,长沙市,中南大湘雅医学院人体解剖学和神经生物学系
- 2. 510120,广州医学院第二附属医院
- 3. 510260,广州三九脑科医院
- 折叠
摘要
Abstract
Objective To explore relationship of plasma homocysteine (Hey) level and polymorphism of methionine synthase reductase (MTRR) with intracranial aneurysm. Method The genotyes of MTRR were determined by PCR-based assay and their plasma Hey levels were determined in 76 patients with intracranial aneurysm and 77 healthy controls. Results Mean total plasma Hey concentrations were significantly higher in intracranial aneurysm patients than in the normal subjects. Aneurysm group MTRR A66G AA genotype and A allele frequencies were higher than the normal (P < 0.01) , the risk of intracranial aneurysm patients is 7.30 and 2.41 times than the control group. MTRR A66G genotype TC, TG, Hey concentration group comparison showed that different genotypes aneurysm group TG, TC showed no significant difference (P > 0.05) , AA genotype with high Hey levels than other genotypes, with significant significance (P < 0.05), aneurysm group Hey concentrations than the control group, with significant differences (P < 0.05) , but the two groups of TG and TC levels were not significantly different (P > 0.05), the control group between the different genotypes TG, TC, Hey levels were not significantly different (P > 0.05). Conclusions Hyperhomocysteinemia may be independent risk factors for intracranial aneurysm and MTRR A66G of the AA genotype may be the independent genetic risk factors of intracranial aneurysms.关键词
动脉瘤/同型半胱氨酸/蛋氨酸合成酶还原酶/基因多态性Key words
Aneurysm/ Homocysteine / Methionine synthase reductase / Polymorphism引用本文复制引用
陈盛强,罗学港,戴文伟,许绍强,孙卫文,邓维意,伍建伟,李明昌,何伟文,陆永健..同型半胱氨酸及其代谢关键酶MTRR基因多态性与颅内动脉瘤的关系[J].实用医学杂志,2011,27(19):3522-3525,4.
