医药导报2011，Vol.30Issue(11)：1425-1429,5.DOI:10.3870/yydb.2011.11.007
山药参芪丸毒性与治疗大鼠2型糖尿病效果评价
Security and Pharmacodynamic Test of Yam Shenqi Pill in Treating Type 2 Diabetic Rats
徐彦博 1高永喜 1姚萍 1刘朝华 1王鹏 1李萌 1马宽1
作者信息
摘要
Abstract
Objective In order to provide a theoretical basis for the clinical application of yam shenqi pill, we evaluated the therapeutic effect and safety of yam shenqi pill. Methods The experimental acute and long-term toxicology testing of different doses of yam shenqi pill in normal rats, and the establishment of rat model of type 2 diabetes observed yam shenqi pill on blood glucose and blood lipids. Results In the acute toxicology experiment, various mice's outward appearance, the behavior, the breath, four extremity activities, the feed, the excretion have not seen obviously exceptionally; In the long-term toxicology experiment, the yam shenqi pill treatment groups compared with the control group, in the blood, blood biochemistry and histology were no significant differences ( P>0. 05 ), the treatment of blood glucose ( Glu ) were significantly reduced (P<0.01 or P< 0. 05 ); large, medium dose group and the metformin group can lower total cholesterol ( CHO ), triglyceride ( TG ), low density lipoprotein ( LDL ) levels, a significant difference between results ( P<0. 05 ) each treatment group compared with the model of high-density lipoprotein ( HDL ) levels tended to increase, but the result was no significant difference. Conclusion Acute and chronic toxicity test found no toxicity yam shenqi pill type 2 diabetic rats significantly reduced the Glu, TG and CHO content, prompted by the proposed use of yam shenqi pill, dosage, treatment efficacy in clinical applications precise and safe.关键词
山药参芪丸/糖尿病,2型/安全性/药效学Key words
Yam shenqi pill/ Diabetic, type 2 / Security/ Pharmacodynamic分类
医药卫生引用本文复制引用
徐彦博,高永喜,姚萍,刘朝华,王鹏,李萌,马宽..山药参芪丸毒性与治疗大鼠2型糖尿病效果评价[J].医药导报,2011,30(11):1425-1429,5.
