中国临床药理学杂志2011，Vol.27Issue(9)：682-685,4.
丁苯酞对大鼠脑缺血再灌注损伤后凋亡相关因子表达的影响
Effects of dl-3n-butylphthalide on the expression of apoptosis-related factors in rats with focal cerebral ischemia-reperfusion
李国前 1王杰华 1杨小霞 1洪诸权1
作者信息
- 1. 福建医科大学附属泉州第一医院神经内科,福建,泉州,362000
- 折叠
摘要
Abstract
Objective To observe the effects of dl -3n - butylphthalide (NBP) on the expression of Bel -2 and Bax on cerebral ischemia -reperfusion injury in rats. Methods Forty male adult Sprague - Dawley rats were randomly assigned into four groups: sham operation group (sham group), focal cerebral ischemia - reperfusion group ( model group) , vehicle adminerstration group (vehicle group) , and dl -3n -butylphthalide group (NBP group). The middle cerebral artery occlusion reperfusion model was made by the suture method (ischemia for 2 hours, and reperfusion for 24 hours). After that, rats were sacrificed by decapitation , and the level of Bel - 2 and Bax expression were measured by im-munohistochemical and RT - PCR. Results The expressions of Bel - 2 and Bax were increased significantly in rats with focal cerebral ischemia - reperfusion. Compared with model group and vehicle group, in rats of NBP group, the Bel - 2 expression was up regulated ( P < 0.05), the Bax expression was down regulated ( P < 0. 05 ). Conclusion NBP can relieve the brain damage induced by focal cerebral ischemia - reperfusion in rats, which may significantly be related to the up regulation of Bel - 2 expression and the down regulation of Bax expression.关键词
丁苯酞/脑缺血再灌注/凋亡相关因子Key words
dl -3n - butylphthalide/ focal cerebral ischemia - reperfusion / apoptosis - related factor分类
医药卫生引用本文复制引用
李国前,王杰华,杨小霞,洪诸权..丁苯酞对大鼠脑缺血再灌注损伤后凋亡相关因子表达的影响[J].中国临床药理学杂志,2011,27(9):682-685,4.
