中国脑血管病杂志2011，Vol.8Issue(9)：469-472,4.DOI:10.3969/j.issn.1672-5921.2011.09.005
2型糖尿病患者血清炎性因子与颈动脉粥样硬化的相关性研究
Correlation between serum inflammatory factors and carotid atherosclerosis in patients with type 2 Diabetes
摘要
Abstract
Objective To study the correlation between serum inflammatory factors and carotid atherosclerosis in patients with type 2 diabetes. Methods A total of 124 patients with type 2 diabetes were collected in the study. The levels of serum intercelluar adhesion molecule-1 (ICAM-1 ) , vascular cell adhesion molecular-1 ( VCAM-1 ) , E-selectin, interleukin-6 (IL-6) and C reactive protein (CRP) were measured with enzyme-linked immunosorbent assay (ELJSA). The patients with diabetes were divided into normal carotid, carotid thickening and carotid plaque groups according to the findings of carotid ultrasound. Forty healthy subjects were used as controls. The levels of serum inflammatory factors were compared in each group. Results ?The levels of serum ICAM-1, IL-6 and CRP in the normal carotid group were higher than those in the control group. The levels of ICAM-1, VCAM-1, IL-6 and CRP in the carotid thickening group were higher than those in the normal carotid group. The levels of ICAM-1, VCAM-1 and E-selectin in the carotid plaque group were higher than those in the carotid thickening group. There were significant differences in the above indicators among each group (P < 0.05 or P < 0. 01). ?Correlation analysis showed that the severity of carotid intima-thickness was positively correlated with HbAlc (r = 0. 472),ICAM-1 (r = 0.501), VCAM-1 (r=0.484), E-selectin (r = 0.289), IL-6 (r=0.425) and CRP (r = 0. 381). The correlation of HbAlc in patients was positively correlated with ICAM-1, VCAM-1, IL-6, and CRP. There was positive correlation among ICAM-1, VCAM-1, E-selectin, IL-6 and CRP (all P <0. 01 or P <0. 05 ). Conclusions The inflammatory response participated in the process of the occurrence of carotid atherosclerosis in patients with type 2 diabetes, and the levels of serum inflammatory factors may reflect the severity of carotid atherosclerosis to some extent in patients with diabetes.关键词
糖尿病,2型/动脉粥样硬化/颈动脉/细胞间黏附分子1/血管细胞黏附分子1/E选择素/白细胞介素6/C反应蛋白质Key words
Diabetes mellitus, type2/ Atherosclerosis/ Carotid arteries/ Intercellular adhesion mole-cule-1/ Vascular cell adhesion molecular-1/ E-selectin/ Interleukin-6/ C reactive protein引用本文复制引用
黄小波,陈文强,李宗信,王宁群..2型糖尿病患者血清炎性因子与颈动脉粥样硬化的相关性研究[J].中国脑血管病杂志,2011,8(9):469-472,4.基金项目
国家自然科学基金资助项目(81041022),北京市自然科学基金资助项目(7102073),北京市中医药科技项目资助(JJ2008-020) （81041022）
