现代妇产科进展2011，Vol.20Issue(9)：685-688,4.
AQP1和AQP3在子宫颈鳞状细胞癌中表达的研究
Expression of AQPI and AQP3 in cervical squamous cell carcinoma
摘要
Abstract
Objective;To explore the expression and significance of AQP1 and AQP3 in cervical carcinoma. Methods: Expression of AQP1 and AQP3 in SiHa cell line was examined by RT-PCR and immunofluorescence, and in 35 cases of cervical carcinoma, 15 cases CIN Ⅲ and 15 cases of chronic cervicitis by immunohistochemistry. Results; (1) AQP1 and AQP3 expressed in SiHa cell line; ( 2) AQP1 expressed in the cytoplasm of stromal vascular endothelial cells in cervical lesions, MVD was used as representing AQP1 expression; MVD were 43. 6± 17.8,56.2±11.6,70.8±21.1 in chronic cervicitis group, CIN Ⅲ group and cervical carcinoma group, respectively . MVD in cervical carcinoma was significantly higher than that in CIN Ⅲ and chronic cervicitis(P<0.05) ,but difference of MVD between CIN Ⅲ and chronic cervicitis was not significant P>0. 05). Positive rates of AQP3 were 13. 33% ,26. 67% ,48. 57% , respectively , in chronic cervicitis group, CIN M group and cervical carcinoma group. Difference of AQP3 expression between cervical carcinoma group and chronic cervicitis group was significant (P<0.05 ), and difference between cervical carcinoma group and CIN Ⅲ, CIN Ⅲ and chronic cervicitis group was not significant (P>0. 05). Conclusion; Expression of AQPland AQP3 in cervical carcinoma may be related with cervical carcinogenesis and development.关键词
AQP1/AQP3/子宫颈癌/SiHaKey words
AQP1/ AQP3/ cervical carcinoma/ SiHa分类
医药卫生引用本文复制引用
史永华,陈锐,拉莱·苏祖克..AQP1和AQP3在子宫颈鳞状细胞癌中表达的研究[J].现代妇产科进展,2011,20(9):685-688,4.基金项目
2010年度国家自然科学基金地区基金项目(No:81060216) （No:81060216）
