现代妇产科进展2011，Vol.20Issue(9)：718-721,4.
脂联素基因多态性与妊娠期糖尿病的相关性研究
Relationship between adiponectin gene polymorphism and gestational diabetes mellitus
陈震宇 1杜鹃2
作者信息
- 1. 中国人民解放军第202医院妇产科,沈阳,110003
- 2. 中国医科大学附属盛京医院妇产科
- 折叠
摘要
Abstract
Objective: To investigate the relationship between adiponectin gene polymorphism and gestational diabetes mellitus. Methods; Adiponectin gene promoter region-11426A>G,-11377C> G polymorphisms were detected by MALDI-TOFMS technique among 103 cases of GDM pregnant women and 97 normal pregnant women. Meanwhile, FINS, FPG, TC, TG, HDL-C, LDL-C, APN were measured among 40 cases of GDM women without any treatment. Results: (1)The AG.GG genotype frequencies of the SNP-11426 were higher in GDM than those in controls( ^2 = 8. 822, P = 0. 012). The G-allele was associated with an increased risk of GDM(x2 = 10.283,P = 0. 001). The differences of SNP-11377 genotype and allele frequencies between GDM and controls were not significant(P>0. 05). (2) Women carrying the G allele of SNP-11426 showed higher TG( P = 0. 023), lower APN levels (P = 0. 024) than those with AA genotype. Conclusions: G allele of SNP-11426 is related to GDM possibly. A→G variation may involve in the occurrence of GDM by reducing serum adiponectin levels.关键词
妊娠期糖尿病/脂联素/单核苷酸多态性Key words
Gestational diabetes mellitus/ Adiponectin/ Single nucleotide polymorphism分类
医药卫生引用本文复制引用
陈震宇,杜鹃..脂联素基因多态性与妊娠期糖尿病的相关性研究[J].现代妇产科进展,2011,20(9):718-721,4.
