现代妇产科进展2011，Vol.20Issue(9)：722-725,4.
母血浆P-LAP与早产发动关系的相关性临床研究
The study of correlation of maternal plasma P-LAP and the onset of pregnancy and preterm labor
熊瑛 1杨祖菁1
作者信息
- 1. 上海交通大学医学院附属新华医院妇产科,上海,200092
- 折叠
摘要
Abstract
Objective;To investigate the relationship between maternal plasma placenta leucine aminopepticlase ( P-LAP) and gestational age during 28 ~ 36+6 weeks' in the normal pregnant women and spontaneous preterm labor women. Methods; These pregnant women were defined as preterm and threatened preterm labor group. Maternal plasma P-LAP and IL-6 concentrations were measured by enzyme-linked immunosorbent assay. Results: (1) P-LAP concentration increased with the gestational age increased in third trimester pregnancy group ( P < 0. 01) ,but IL-6 concentrations did not( P>0.05). (2) The concentration of P-LAP of premature group was lower than that of the threatened premature labor group or the full-term group and the difference was statistically significant(P<0. 01). (3) When the P-LAP levels of the premature group at or below the 10th percentile level of full-term group,the incidence of premature delivery increased compared with threatened premature labor group(P = 0. 008). (4) The plasma levels of P-LAP did not significantly related to IL-6 concentration using linear regression analysis(P>0.05). Conclusion;P-LAP concentration increases with gestational age. A low level of serum P-LAP of the spontaneous preterm pregnant women admitted to hospital can predict their prognosis. The decline of the level of P-LAP may be the key factor of the onset of labor and preterm labor.关键词
胎盘亮氨酸氨基肽酶/白介素-6/早产/先兆早产Key words
Placental leucine aminopepticdase/Interleukin-6/Preterm labor/Threatened preterm labor分类
医药卫生引用本文复制引用
熊瑛,杨祖菁..母血浆P-LAP与早产发动关系的相关性临床研究[J].现代妇产科进展,2011,20(9):722-725,4.
