中国肺癌杂志2011，Vol.14Issue(10)：830-834,5.DOI:10.3779/j.issn.1009-3419.2011.10.11
BRD7在非小细胞肺癌组织中的表达及临床意义
Expression and Clinical Significance of Bromodomain-containing Protein 7 in Non-small Cell Lung Cancer
陈龙 1喻风雷1
作者信息
- 1. 410000,长沙,中南大学湘雅二医院心胸外科
- 折叠
摘要
Abstract
Background and objective 'The bromoclomain-containing proiein 7 (BRD7) gene belongs to the bro-motlomain lamily. The majority of the members of this family are closely related to epithelial tumors. The aim oi this study is to explore BRD7 expression and its clinical significance in non-small cell lung cancer (NSCLC). Methods BRD7 protein expres-sion was detected in tissues samples from 101 NSCLC cases and 33 normal lung tissue samples using streptavidin-peroxidase immunohistochemistry. Results BRD7 expression was significantly higher in cancer tissues than that in normal lung tissues. Positive BRD7 expression in the lympb node metastasis group was significantly higher iban that in the non-lymph node me-tastasis group. The positive expression rate ol BRD7 increased with the increasing Tumor-Nodes-Metastasis (TNM) siage. Mo significant differences in positive BRD7 expression were observed witb age, smoking, gender, patbology typc, and degree of differentiation among the NSCLC patients (P>0.0S). Conclusion BRD7 is highly expressed in NSCLC. In addition to the de-gree of differentiation and extent of lymphatic metastasis, BRD7 expression is correlated with TNM stage, which indicates that BRD7 may be related to the occurrence, development, and metastasis of lung cancers.关键词
肺肿瘤/溴区包含蛋白7/免疫组化Key words
Lung neoplasms/ Bromodomain-containing protein 7/ Immunohistocliemistry分类
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陈龙,喻风雷..BRD7在非小细胞肺癌组织中的表达及临床意义[J].中国肺癌杂志,2011,14(10):830-834,5.
