新医学2011，Vol.42Issue(8)：510-512,3.DOI:10.3969/g.issn.0253-9802.2011.08.009
白花蛇舌草提取物对鼻咽癌细胞株CNE1的毒性及其机制
Cytotoxicity and its mechanisms of the extracts of Herba hedyotis to nasopharyngeal carcinoma cell line CNE1
摘要
Abstract
Objective; To investigate the cytotoxicity and its mechanisms of the extracts of Herba hedyotis to nasopharyngeal carcinoma cell line CNE1. Method; CNE1 cells were treated with water soluble, lipid soluble or polysaccharide extracts of Herba hedyotis, respectively. The potency of these extracts to inhibit cell growth was de-tected by CCK-8 assay. The apoptotic rate was detected by annxin V-FITC apoptotic detection assay. Results; All of the three kinds of extracts of Herba hedyotis inhibited cell proliferation of CNE1 cells in dose and time dependent manner. Among them, the cytotoxity of the lipid soluble extract was the most significant, and then the water soluble one. There were significant differences between different groups (P <0.05). The lipid soluble extract could induce the apoptosis of CNE1 cells in dose and time dependent manner. Conclusion; The extracts of Herba hedyotis had cytotoxicity to nasopharyngeal carcinoma cell line CNE1. And the lipid soluble extract had the most significant cyto-toxicity , which might involve the induction of the cell apoptosis.关键词
白花蛇舌草/鼻咽癌/增殖抑制/凋亡Key words
Herba hedyotis/ Nasopharyngeal carcinoma/ Inhibition of proliferation/ Apoptosis引用本文复制引用
刘汝青,邓雪清,肖勇梅,曾永长,魏青..白花蛇舌草提取物对鼻咽癌细胞株CNE1的毒性及其机制[J].新医学,2011,42(8):510-512,3.基金项目
广东省中医药局科研课题(2008085) （2008085）
