军事医学2011，Vol.35Issue(10)：791-794,4.
泛素连接酶CUL4A-DDB1复合体参与DNA损伤修复的研究进展
Progress in functional regulation of CUL4A-DDB1 ubiquitin ligase on DNA damage and repair
摘要
Abstract
Ubiquitylation of protein plays an important role in DNA damage signaling transduction, including cell-cycle control, DNA repair, aging, as well as apoptosis. CUL4A-DDB1 E3 ligase recruits substrates through DCAFs for ubiquitylation and initiates the process of DNA excision repair for the removal of damaged DNA. Recent data suggest that the role of CUL4A-DDB1 E3 ligase is critical in genomic stability by regulating DNA damage, DNA repair, and DNA replication.关键词
泛素蛋白连接酶类/DNA损伤/DNA修复/泛素化修饰/细胞周期/细胞衰老Key words
ubiquitin-protein ligases/ DNA damage/ DNA repair/ ubiquitylation/ cell cycle/ cell aging分类
生物科学引用本文复制引用
谢萍,焦杨,周颖,柳向军,张令强,贺福初..泛素连接酶CUL4A-DDB1复合体参与DNA损伤修复的研究进展[J].军事医学,2011,35(10):791-794,4.基金项目
国家重大科学研究计划课题(2007CB914601) （2007CB914601）
国家自然科学基金项目(30800584,30800177)部分资助 （30800584,30800177）
